As one third of the world’s population is infected with M. tuberculosis along with this new and relapse cases of tuberculosis are reported every year. The emergence of new cases, increased incidence of multi-drug resistant strains of M. tuberculosis and the side effects of existing first- and second-line antituberculosis drugs have led to hope of discovering new antitubercular drug molecules. The increase in demand for the synthesis of new antitubercular agents is due to the developing resistance towards existing drugs. The present review explores active triazole, thiazolidine, pyridine, oxazolidinone derivatives having antitubercular activity published during the last 10 years. Also, critical aspects of structure activity relationship with respect antitubercular activity have been encompassed. The present endeavor will of cognitive importance for further research on the potential use of said heterocyclic nucleus towards anti-tubercular activity.
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